Interleukin-7. Biology and implications for dermatology
نویسندگان
چکیده
منابع مشابه
The biology and medical implications of interleukin-6.
Cytokines are soluble mediators, which aid cell-to-cell communication in immune responses, and interleukin-6 (IL-6) is a prototypical cytokine featuring redundant and pleiotropic activity. The complete elucidation of the IL-6-mediated signal transduction system has provided a molecular basis for the characteristic features of cytokines. When tissue damage or inflammation due to infections or in...
متن کاملInterleukin-7 and Interleukin-15 for Cancer
Interleukin 7 and 15 are considered powerful pro-inflammatory cytokines, they have the ability to destabilize chromosomes and induce tumorigenesis. Additionally, they can control malignancy proliferation by influencing the tumor microenvironment and immune system. Immunotherapy has been proposed as a treatment modality for malignancy for over a decade; the exact mechanisms of action and pathway...
متن کاملJournal of Dermatology and Skin Biology
Atopic dermatitis (AD) together with asthma and allergic rhinitis represents the most typical manifestation of “atopic constitution”. AD was known since ancient times and also Job was probably affected by it. In the Bible (Book of Job) we read:” So went Satan forth from the presence of the Lord and smote Job with sore boils from the sole of his foot unto his crown; and he took him a potsherd to...
متن کاملHuman Cancer Biology Interleukin-7 Inhibits Tumor-Induced CD27 CD28 Suppressor T Cells: Implications for Cancer Immunotherapy
Purpose: We have previously reported that many types of tumors can induce changes in human T cells that lead to the acquisition of suppressive function and phenotypic alterations resembling those found in senescent T cells. In the present study, we find a role for interleukin 7 (IL-7) in protecting T cells from these changes and further define involved signaling pathways. Experimental Design: W...
متن کاملJournal of Dermatology and Skin Biology
Introduction: Melanomas show a wide variation in pigmentation. The present study evaluates the role of angiogenesis in reprogramming/remodeling of the tumor through tumor vascular interactions. Methods: Paraffin and frozen sections from melanomas in vertical growth phase, were subjected to routine, enzyme/Immunohistochemistry, and electron microscopy. Quantitation was done by morphometric analy...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Experimental Dermatology
سال: 1996
ISSN: 0906-6705,1600-0625
DOI: 10.1111/j.1600-0625.1996.tb00107.x